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The profibrotic and proinflammatory mediators of SASP stimulate the infiltration of immune cells and tubular cell damage generating in persistent tubulointerstitial inflammation, the proliferation of fibroblasts, and extreme extracellular matrix deposition augmenting kidney damage and the progression to CKD

In vivo studies show that such targeted enhancement can increase inhibitory neuron spiking, rebalance excitatory-inhibitory activity in the AC, and even prevent noise-induced tinnitus, offering a mechanism-based strategy that avoids general receptor blockade (Deng et al., 2020a)

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Similarly, vitamin C influences melanin production by inhibiting tyrosinase, an enzyme involved in melanin formation, thereby reducing its levels