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doi: 10.1016/j.gene.2012.08.038 594 SonYKimSChungHTPaeHO

2020;5(9):e132747

Conversely, metal ions can form stable complexes with chelators, altering their chemical properties and affecting their ability to interact with cellular targets

It all depends on formulation

The mechanism of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1alpha and TNF-alpha, which stimulate secretion of endothelin 1