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This bidirectional regulatory loop may act as a hot spot ensuring proper transitions of NSCs between quiescence, proliferation, and differentiation under oxidative or inflammatory stress

In addition, extracellular lactate stabilizes HIF-2, and HIF-2 then transactivates MYC, increasing the levels of glutamine transporters and GLS1, in turn resulting in increased glutamine catabolism 72

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doi: 10.1111/nyas.2016.1376.issue-1 55 CarlbergCVelleuerE