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Most experienced researchers settle on 300-500mcg as the optimal daily dose

After 12 treatment sessions, patients were assessed for pain intensity, knee flexion range of motion, a timed up-and-go test, a 6-min walk test, and knee functionality compared to pre-treatment baseline measurements

Unlike vitamin B12 deficiency, which produces well-recognised neurological and haematological problems, hypercobalaminaemia (elevated B12) is typically asymptomatic