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Yu B, Qi Y, Li R, Shi Q, Satpathy AT, Chang HY

doi:10.1016/j.pharmthera.2009.07.003 Purves D, Augustine GJ, Fitzpatrick D, et al

Thus, robust mitochondria = slow aging

Of note, among the most characterized targets of NRF2, haem oxygenase 1 (HMOX1) has been found to be synthetic lethal with FH 8 suggesting that the activation of NRF2 and its downstream targets might have an important prosurvival role in Fh1-deficient cancer cells, beyond the control of redox homeostasis