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Melissa officinalis L: A Review Study With an Antioxidant Prospective

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It is a self-sustaining system consisting of small molecules such as vitamins E and C, glutathione 59,60 , and antioxidative defense enzymes, such as superoxide dismutase 61 , catalase 62,63 , glutathione peroxidase, glutathione reductase, and glutathioneS-transferases 62

Bischoff SC, Barbara G, Buurman W et al (2014) Intestinal permeabilitya new target for disease prevention and therapy

Oxidants = reactive oxygen species (ROS) / free radicals Antioxidants = molecules that neutralise ROS by donating electrons This is fundamentally a REDOX imbalance Free radicals are electron-deficient molecules that: Steal electrons from healthy cells Trigger chain reactions of oxidation Damage: Cell membranes (lipid peroxidation) Proteins (enzyme dysfunction) DNA (accelerated ageing, impaired repair) In SKIN, this translates to: Fine lines & wrinkles Loss of elasticity Pigmentation irregularities Impaired barrier function Chronic inflammation UV radiation ( primary extrinsic ageing factor ) Pollution & cigarette smoke Inflammation (acne, rosacea, dermatitis) Poor sleep & psychological stress Aggressive aesthetic treatments without adequate antioxidant support Antioxidants donate electrons without becoming unstable themselves, effectively terminating free-radical chain reactions and reducing OXIDATIVE STRESS