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IGF-1R in the nucleus The functional relevance of nuclear IGF-1R is underscored by reports that it is linked to increased IGF-induced proliferation, resistance to the EGFR inhibitor geftinib, and enhanced tumorigenicity [120,121,122]

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doi:10.1002/jcsm.12208 Jagim AR, Harty PS, Camic CL

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Myo-inositol and D-chiro-inositol supplementation were shown to have a beneficial effect by helping women with PCOS to become ovulatory, also to balance hormones, and restore metabolic health in PCOS (polycystic ovary syndrome) patients [25]