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Dosimetric modulation of the delivered beams according to the prescription plan shows optimistic clinical results, particularly in locally advanced tumors [19]

Hyperglycemic conditions also induce TNF expression in cardiomyocytes, which alters DNMT activity and promotes methylation of the SERCA2a gene promoter, leading to reduced SERCA2a expression, calcium overload, and subsequent diastolic heart failure [121]

Moreover, thyroid cancer risk was observed to be higher in obese people, and female patients with type 2 diabetes mellitus (T2DM) are more likely to have the extra-glandular invasion of PTC than male T2DM patients (126, 127)

however, some degree of hemolysis persists in post-splenectomy HE patients that indicates an incomplete response to splenectomy [8]

and the free radical reactions engendered by TNFa erode GSH concentrations