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In ccRCC, the balance between GSH and GSSG is tightly regulated

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This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

Role of notch signal transduction in Kaposis sarcoma-associated herpesvirus gene expression