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Whole-cell patch clamp demonstrated the amplitude of TRPM3 currents after stimulation with pregnenolone sulphate (a fast reversible TRPM3 activator) is significantly reduced in isolated NK cells from ME/CFS patients compared with healthy controls [64, 157]

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Collectively, these data underscore that optimizing curcumin formulations is critical to overcoming its intrinsic pharmacokinetic limitations

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In addition, the ketogenic diet has a better response when used as an additional treatment along with antiseizure medications [111]