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A recent study demonstrated interorgan immune communication, showing that gut-derived immune cells migrate to distant tissues [255]

Specifically, the % change of in the L-C intervention arm was 9.3% (p = 0.02) greater than in the placebo arm, which corresponded to an absolute between arm difference of 2.7% ( p = 0.03)

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Our replication cohort comprised 968 study participants without self-reported diabetes of the SHIP-Trend (Study of Health in Pomerania) study [28], for whom mass-spectrometry (MS)-based plasma metabolomics as well as 9-item Patient Health Questionnaire (PHQ-9) data were available