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Calcium homeostasis dysregulation impacts A aggregation, tau hyperphosphorylation, synaptic damage, neuronal apoptosis, mitochondrial dysfunction, oxidative stress, and neuroinflammation [69,70,71,72,73,74,75]

Andrea Baccarelli, Dean of the Harvard T.H

Furthermore, sulfasalazine (SSA) and buthionine sulphoximine (BSO), which are inhibitors targeting NAC and GSH metabolism respectively, suppressed the tumor promoting effects induced by NAC and GSH in vitro and in vivo, and accompanied with significant increase in ROS level