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Lactate in TGF-1-induced lung myofibroblasts and in BAL fluids (BALFs) from TGF-1- or bleomycin-induced mice induces histone Kla, particularly histone 3, in profibrotic gene promoters in macrophages, contributing to lung fibrosis

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To determine whether SOX2 + cells contributed to acinar and duct lineages, we performed genetic lineage tracing using Sox2 CreERT2 mice (Arnold et al , 2011) crossed to a Rosa26 mTmG reporter strain

The molecules, in the radical form, give an absorbance at 515 nm, which disappears after acceptance of hydrogen or an electron from an antioxidant compound to become a diamagnetic stable molecule (326)