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weight-based dosing of azathioprine in Crohns disease

A major limitation is the poor predictive value of commonly used animal models, which often fail to accurately reflect human immune responses and disease progression (Ortega-Tirado et al., 2020)

These include targeting proteins involved in inflammatory pathways, such as IB kinase (309) and Shp2 (310), as well as long non-coding RNAs like growth arrest-specific transcript 5 (GAS5) (311) and membrane proteins like Nogo-A and its associated receptor NogoR-1 (312)