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doi: 10.1016/j.celrep.2021.108771 Summary Keywords childhood cancer, neuroblastoma, combination therapy, oxidative stress, DPI, MitoQ, metabolism Citation Epp S, Egan D, Poon E, Abdul Aziz AA, Wynne K, Chesler L, Halasz M and Kolch W (2025) Oxphos targeting of MYCN -amplified neuroblastoma

Research Considerations Outcomes may vary with diet, environmental conditions, and protocol design ERR agonist effects appear to be synergistic with concurrent exercise in animal models Compound handling and capsule storage should be standardized across a study Co-administration with other ERR-active or mitochondria-targeting compounds has not been characterized Administration SLU-PP-332 in the 250 mcg capsule form is taken orally

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