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Deficiency symptoms include anaemia, fatigue, neurological manifestations such as paraesthesia and balance problems, and glossitis, with neurological damage potentially irreversible if untreated

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M9a + sh EPAS1 cells promote mitochondrial function and inhibit cell apoptosis during hypoxia Previous studies have demonstrated that EPAS1 exhibits the strongest selection signal and is downregulated in Tibetans [3,4,5]