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Studies have shown that plasma TMAO may affect the course of various cardiovascular disorders and increase the risk of MI, despite the lack of direct relationships [65, 79]

A more recent, larger study confirmed these results, finding that the rate of isotretinoin-induced acne flaring dropped significantly from 30% in those who received isotretinoin alone down to 5% in the group that took isotretinoin plus levocetirizine 2

There was a positive relationship between extent of burn and carnitine output [1]

Therefore, in analyses regarding fatigue and sleep impairment, we chose to use levels of androsterone sulfate, an indicator for the effectiveness of ADT (Chi et al., 2020), instead of a binary classification (+ADT vs

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