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All families whose children participated and completed the 90-days trial period received a signed form by the principal investigator with instructions about how to contact the manufacturer of CRWP (Immunocal, Immunotec Inc., Montreal, Canada) to obtain the supplement quarterly at no extra cost for up to 3 years (this was voluntary if the parent signed and gave consent)

This modification induces thermodynamic destabilization and conformational changes, eventually resulting in increased solvent-exposed hydrophobicity 155