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Proponents argue that the current Biden-era restrictions on compounding of the substances due to safety concerns and a lack of data have fueled a gray market of overseas suppliers, raising safety concerns as Americans inject themselves with unvetted substances

Another RAMIRIS trial compared the safety and efficacy of FOLFIRI plus ramucirumab with paclitaxel plus ramucirumab for the same patients, and the results showed that FOLFIRI plus ramucirumab has a relative advantage in terms of the objective response rate (ORR), mPFS, and mOS (69)