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Comorbidity-specific signatures include: diabetic stroke with paradoxical glycolysis suppression and accelerated lipid peroxidation [185]

Evidencia cientfica La evidencia disponible sobre esta combinacin proviene de estudios farmacolgicos independientes de cada componente y de trabajos preclnicos sobre secretagogos de GH

The major UPR transducers operate through biochemically distinct mechanisms

The neuroinflammation is characterized by the activation of microglia, astrocytes, macrophages and lymphocytes, which over express mediators such as cytokines, chemokines, prostaglandins, acute proteins, neurotransmitters and ROS/RNS [232, 233]

Currently, there are no approved medications for the treatment of FXS, with the approaches under study being fairly specific and unsatisfying in human trials