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These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

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It plays a critical role in maintaining cellular health by neutralizing free radicals and reactive oxygen species, which can cause oxidative stress and damage to cells

The epididymis, heart, lung, liver, brain, adipose tissue, mammary gland, and digestive system are among the several other organs in which GPx3 is also present in activated form