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Combined inhibition of LDHB and SLC7A11 synergistically suppresses KRAS -mutant tumor growth by inducing ferroptosis in vivo We validated our in vitro findings in KRAS -mutant lung cancer xenografts and a genetically engineered mouse (GEM) model of autochthonous Kras G12D -induced lung adenocarcinoma that accurately resembles human disease [20]

Simon M, Wang MX, Ismail O et al (2022) Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid plaque formation in mice

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There is no single gold standard for assessing histologic activity in ulcerative colitis, and none of the currently available histologic scoring indices have been fully validated

857,858 Single-cell RNA sequencing analysis revealed a new subgroup of inflammatory chondrocytes with regulatory potential in the microenvironment of hand osteoarthritis