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Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

Indeed, GSH, Trx, Grx, Prx (together with the enzymes catalyzing their reduction), and the enzymatic antioxidant defense, as a whole, concur to modulate either ROS concentration, or the availability of cellular thiols, thus regulating the function of a large number of proteins implicated in the induction and/or execution of redox-sensitive pathways

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These decrease over time for most researchers