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Skeletal & Cardiac muscle

Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR)

Caron P, Grunenwald S, Persani L, Borson-Chazot F, Leroy R, Duntas L

"This is a situation in which a patient could become septic very quickly if left untreated." Risk factors for kidney stones Approximately 1 in 10 people will develop kidney stones

This results in most of the drug disposition occurring in the central regions of the lungs instead of reaching the peripheral areas where they are most required in achieving the most therapeutic benefit