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The knock-in animals have mostly achieved attention as models of FXTAS

10.1126/science.1090389 Science 246 Wislet-GendebienS.VisanjiN

As your melanocytes (pigment cells) are incredibly sensitive

-glutamyltranspeptidase cleaves glutathione at the unique -glutamyl bond to form free glutamate and the dipeptide Cys-Gly, which is degraded to Cys and Gly for transport in to cells via amino acid transporters