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Furthermore, 3-mercaptopyruvate sulfurtransferase-derived mitochondrial H2S may play a regulatory role in BCAA catabolism and mediate critical cardiovascular protection in heart failure (74)

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Here we show that SIRT3, a mitochondrial deacetylase highly expressed in HSCs but reduced during aging, suppresses the HSC response to aging that drives maladaptive trained immunity, chronic inflammation and tissue functional decline in mice

10.3390/nu16070924 23 PangY.LinY.WangX.WangJ.LiuQ.DingN.et al (2022)