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Behav Neurosci

This chelation may limit metal-catalyzed Fenton-type reactions and thereby reduce hydroxyl radical formation [5, 26]

Interestingly, SOD is an antioxidant enzyme that promotes the breakdown of O 2 radical into O 2 and H 2 O 2 , thereby annihilating oxidative damage ( 2 O 2 and lipid hydroperoxides, as well as direct neutralization of AFT (by forming an AFTGSH conjugation) ( are built up, which aggressively attack the phospholipid membrane, leading to MDA accumulation ( Accordingly, oxidative damage is prominently emphasized in our study, expounded by an evident drop in GSH levels and the activities of SOD and GPx in renal tissues