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This may happen, for example, with olanzapine, which has a half-life of 2154 hours

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Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis

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LC-ESI-QTOF method for the targeted metabolomics analysis The samples were analyzed by a 1290 Infinity II LC instrument coupled to a 6546 LC/Q-TOF high-resolution mass spectrometer, and the ionization was performed using a Dual Jet Stream source in negative mode (Agilent Technologies, Waldbronn, Germany)