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This can complicate clinical trials by making it difficult to attribute outcomes to the new agent, potentially affecting efficacy assessments and regulatory approval (Theuretzbacher and Piddock, 2019)

The DM-associated metabolic-immune axis further manifests in alveolar pathophysiology: obesity and T2DM induce alterations in surfactant synthesis within alveolar type II epithelial cells (Schipke et al., 2021)

Preferential induction of the T cell auxiliary signaling molecule B7-H3 on synovial monocytes in rheumatoid arthritis

Diagnosis is based on the detection of reduced specific enzyme activity and molecular characterization of the defect at the DNA level [49,50]

We thank Mrs PC Yajnik for administrative support