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In the new structure, residues close to GSH are: A35, R38, L39, K42, R73, H76, L77, L80 from one subunit and R74, L77, N78, E81, Q127, N129, R130 from its neighbour

D., Flanagan, J

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edited and reviewed the manuscript

We found that PA-S14 promotes mitochondrial biogenesis via LKB1-AMPK-PGC-1 signaling pathway, which protects against renal TECs cell senescence, renal fibrosis in various CKD models, such as unilateral ureteral obstruction (UUO), unilateral ischemia-reperfusion injury (UIRI), adriamycin nephropathy and 5/6 nephrectomized model (Liu et al., 2022a) (Table 1)