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It is possible that iron overload and iron-mediated free radical production cause the loss of TJs proteins and degeneration of endothelial cells, and that targeting iron mediated oxidative stress provides an extended therapeutic time window against an ischemic event (Park et al., 2011

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PCR was used to confirm that the gene had been deleted in the resulting transformants, as shown in Figure 1A

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Instead, it may take experimenting with several of the options listed above for several days or a week at a time