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Two Valve Structures Become One Before discussing progress toward regaining continence, its important to explore why a radical prostatectomy causes incontinence in men

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2023 (6) CD014788

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To circumvent this difficulty and to reduce the possibility of suppressor mutations that compensate for chronic loss of V-ATPase structural or assembly genes, we fused an AID* degron domain (a 71-114 truncated fragment of the IAA17 protein that proved to work efficiently in budding yeast) 24 to the endogenous Vma2 protein