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10.1016/s0014-2999(97)01033-9 121 SikiricP.SeiwerthS.MiseS.StaresinicM.BedekovicV.ZarkovicN.et al (2003)

Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics The concomitant use of opioids with other opioid analgesics, such as butorphanol, nalbuphine, pentazocine, may reduce the analgesic effect of hydrocodone bitartrate and acetaminophen tablets and/or precipitate withdrawal symptoms

The iron chelation activity of curcumin is related to its chemical structure via the -diketone group, a known bidentate chelator of Fe 2+ , similar to the group found in simple analogous complexes of Fe(III) and acetylacetonate

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Endorphins muffle your perception of pain and boosts feelings of pleasure, creating a temporary but strong sense of well-being