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In this experiment, calibrated Von Frey filaments were employed to evaluate joint pain sensitivity as previously described 38,39 , the results showed that metformin treatment increased the paw withdrawal thresholds compared with those in MIA-induced OA model group (Fig

Bioorthogonal Conjugation: Developing chemistries that preserve metal-ligand coordination to maintain activity in ID-ADCs (Rossin and Robillard, 2021)

The medication is primarily eliminated through protein catabolism rather than traditional hepatic metabolism, meaning liver disease typically does not substantially affect elimination rates

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Release 219 , 500518 (2015)