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The dual HPLC and mass-spec approach is the correct standard, since purity and identity are separate questions and a compound can be pure yet incorrectly identified

10.1515/jcim-2020-0090 70 Hee-HyunL.KuiJinK.OkHwanL.Boo-YongL

The newly generated pyruvate later crosses the mitochondrial inner membrane in favor of presumptive pyruvate transporters MPC (MPC1 and MPC2) and/or MCT1 (16, 49), to transform into acetyl-CoA for entering the tricarboxylic acid cycle (TCA) and therefore producing 1417 ATPs per lactate molecule for maintaining neuronal activity (26)

The primary source of cystine in GSH synthesis is available through the cystine-glutamate antiporter xCT

doi:10.1016/j.mce.2013.06.014 Watanabe I, Tomita A, Shimizu M, Sugawara M, Yasumo H, Koishi R, Takahashi T, Miyoshi K, Nakamura K, Izumi T, Matsushita Y, Furukawa H, Haruyama H, Koga T (2003) A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus