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(1974) was complicated by the use of other antidotes

doi: 10.1016/8756-3282(93)90310-7

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However, while 16 days of L-citrulline supplementation at a daily dose of 3.4 g significantly increased plasma citrulline, arginine, and nitrite levels, and increased muscle oxygenation during moderate-intensity (70% VO 2 peak) exercise, there were no superior effects on time-to-exhaustion during high-intensity (90% VO 2 peak) exercise

The therapeutic use of peptides began in the early 20th century, marked by the discovery and clinical use of insulin