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113 Its mechanism of action is related to the activation of the Keap1/Nrf2 signaling pathway, manifested by a decrease in the accumulation of malondialdehyde, ROS, and lipid hydroperoxides in cells, an increase in the level of glutathione, and an enhancement in the expression of glutathione peroxidase 4 and solute carrier family 7 member 11

Keywords homocysteine homocysteine-related compounds sulfur-containing amino acids HPLC determination derivatization 1

Metabolomics Systematic identification and quantification of metabolic products (metabolites)

This was the starting point of the study by Gelstein et al

TIG 37 , 10121027 (2021)