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We hypothesize that these metabolic disturbances are linked to inflammation in a bidirectional manner with disturbed gut microbiota as a potential contributing factor

Ann Rheum Dis 69:12271231 Mustonen A-M, Sisnen L, Karttunen L, Julkunen P, Esrafilian A, Reijonen J, Mki J, Krger H, Arokoski J, Nieminen P (2025) Plasma amino acids reflect cartilage loss, osteoarthritis pain, functional disability, and mental health in a longitudinal study with total knee replacement, manuscript in revision

In a study, foliar-applied AsA has been found very effective in improving the growth of strawberry plants under high temperature (44C) (Ergin et al., 1 AsA improved the seedling growth and yield production of maize under low temperature stress (Ahmad et al., 2008) reported that the allele of the gene for monodehydroascorbate reductase (MDHAR) (which catalyzes monodehydroascorbate to ascorbate), responsible for high AsA content in fruits, is usually found active at different fruit ripening stages

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