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Furthermore, these nanocarriers are capable of depleting GSH levels in the tumor microenvironment to augment stress on cells and induce cell death pathways, including ferroptosis, making cancer cells sensitive to treatment Fig

Strikingly, although the placenta is an important site of estrogen biosynthesis and a rich source of estrogens and estrogen signaling factors, potential estrogenic properties of placental materials remain virtually unexplored (Kong et al., 2008

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In human cell culture, Jakubowski (1997) showed that the thiolactone produced by an altered homocysteine metabolism may be incorporated into cellular and extracellular protein through lysine acylation by its activated carboxyl group

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