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ACS Nano 15 (11), 1698217015

It also regulates cyclin D1 and p21 to promote cell proliferation (Waris and Ahsan, 2006)

Invest New Drugs 2021, 39:114

reported that downregulated IIS increased tau phosphorylation, promoted GSK activation, and decreased insulin receptor substrate-1 (IRS1), phospho-Akt, drebrin, and postsynaptic density (PSD95) resulting in cognitive impairment in the HFD model [156]