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Clinical interpretation is made more difficult by the absence of established reference ranges for biofluid indicators such as lipid peroxides and CSF iron

Bolton, S

They include those for transporting transferrin, LDL (low density lipoprotein), insulin, etc., with transferrin receptor-mediated endocytosis being the most investigated and successful one for developing a brain targeting agent

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With old age, specifically with the onset of AD pathology, it is believed that A had either lost its physiological capacity or gained pathological traits or maybe both