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In contrast, the other two substitution mutants, GSAAT(C168S) and GSAAT(C190S), and the corresponding double mutant, displayed hardly any increase in activity under reducing conditions

The regulatory mechanisms include anti-inflammatory, anti-oxidative, anti-apoptotic processes and autophagy regulation, as well as increases in cerebral blood flow and enhancements in the plasticity of synaptic pathways [123]

However such improvements are not seen with infusions of autologous T cells deficient in IL-4 receptors [154]

Nguyen K, Yan Y, Bartholomeusz C, Ueno N, K-A D, Andreeff M , Battula VL

[Abstract]2023 Mar;8(3):410-423