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Active site loop architecture is important in the efficient processing of small glucuronide substrates To explain the range of catalytic efficiencies exhibited by our panel of GUS enzymes, particularly the poor processing activity demonstrated by the new L1 GUS enzymes, we manually docked p NPG into the active site of each GUS enzyme (Figs 4 and 5)

Mendes IKS, Matsuura C, Aguila MB et al (2018) Weight loss enhances hepatic antioxidant status in a NAFLD model induced by high-fat diet

doi: 10.3390/ijms19040954 39

Moreover, both coimmunoprecipitation and confocal microscopy studies showed that PMA promoted the interaction between cPKC and GSTP in LPS-unstimulated cells, while GF109203X inhibited the binding of cPKC to GSTP in LPS-stimulated cells (Figures 6D,E)

By halftime, hed hit six