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Others found decreased Mfn1, Mfn2, and Opa1 levels combined with increased mitochondrial fission in primary neurons from Fmr1 -KO mice [334]

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Sirolimus selectively increases circulating Treg cell numbers and restores the Th17/Treg balance in rheumatoid arthritis patients with low disease activity or in DAS28 remission who previously received conventional disease-modifying anti-rheumatic drugs