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The most accepted hypothesis suggests that chronic inflammatory reaction at the site of injection provides a trigger for subsequent malignant transformation (Hartmann et al., 2015)

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In addition, exogenous IGF-1 administration has been shown to reduce serum glucose levels [95, 143, 144], not only in healthy individuals [140, 145147], but also in those with insulin resistance [148, 149], type I [150152], and T2D [153155]