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Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone

Therefore, further well-designed clinical trials are necessary to confirm kefirs efficacy, safety, and long-term cardiovascular benefits in humans

For example, in the male reproductive system, melatonin can inhibit the expression of key steroidogenic genes (such as p450scc, p450c17, and StAR) in Leydig cells via MT1 receptors, thereby reducing testosterone synthesis (66) to inhibit sexual maturation, spontaneous ovulation, and the estrous response (67)