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Analysed in blood, the effect of interferents originating from this biological matrix, which may be whole blood, serum, plasma or dried blood, is unknown for many analytes of interest

Science 366 , 203210 (2019)

Prx1 is primarily located in the cytosol, nucleus, and peroxisomes, but it can also be detected in serum [50]

My personal protocol to keep my periods regular is eating for blood sugar balance, eating a high-protein diet, taking thyroid meds on an empty stomach, reducing caffeine intake (no more than three cups of black tea per day), taking two capsules per day of MTHFR Pathways , taking 2000 mg of myo-inositol per day (which is actually closer to a PCOS dose of myo-inositol than the Hashimotos dose of 600 mg), and trying Beeya seed cycling

Some of these factors are the results of surgeries, genetic factors or chronic conditions which might require higher levels of B12 to ensure that enough is being absorbed by the body