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Full protocol with comprehensive search strategy, filters, keywords, and combinations is available in Supplementary material 1

These CO measurements capture a physiologically relevant readout of persistent mitochondrial stress and cumulative damage

In PD, misfolded syn and neuronal damageassociated molecules (e.g., ATP, HMGB1) activate microglia through pattern recognition receptors including TLR2 and TLR4 [14], triggering a proinflammatory phenotype with cytokines (TNF and IL1) and ROS release [15]

For deeper ammonia removal, I recommend targeted amino acids that help with detoxification, such as NOW Foods Ornithine (500-2000 mg) at bedtime

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