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Another Gln transporter SLC1A5 inhibitor, V-9302, selectively blocked Gln uptake by TNBC cells, promoted the activation of CD4 + and CD8 + T cells, and reduced Treg levels in a TNBC mouse model (Table 1)

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As a result, Nrf2 escapes degradation and translocate to the nucleus, where it binds to Antioxidant Response Elements (AREs) within the promoter regions of target genes

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