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Apr 2008;8(3):305-312

IL-1alpha/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice

These so-called exTregs lose Foxp3 expression and are thought to be proatherogenic given the loss of their atheroprotective suppressor functions and the initiation of proinflammatory cytokine secretion 2

Building on these findings, PGC1 pathway to promote mitochondrial biogenesis and antioxidant defenses (upregulating enzymes like GPX4 and SOD2)